Effects of Botulinum Toxin (BoNT) and Factors on Weight Loss in Normotonic Pylorus (NP) and Hypotonic Pylorus (HP) Patients at Multivariate Level

Background: In this retrospective research, it was aimed to evaluate effects of botulinum toxin (BoNT) and factors on weight loss in normotonic and hypotonic pylorus patients at multivariate level.

Methods: A total of 671 patients attempted to our clinic between 2020 July to 2022 July were subjected to the study divided by two groups as NP (n=581) and HP (n=90).

Results: Most of patients were female in both groups were females, but male rate in NP group was significantly higher (p<0.05). BMI, weight, weight difference and BMI difference means were significantly higher in NP group (p<0.05). Ursactive rate was significantly higher in HP group (p<0.05). Weight difference was significantly correlated with group (r=-0.267; p<0.01), gender (r=0.161; p<0.01), BMI (r=0.303; p<0.01), BMR (r=0.267; p<0.01), height (r=0.143; p<0.01), weight (r=0.328; p<0.01) and medicine usage (r=-0.082; 0.05). BMI difference was significantly correlated with group (r=-0.262; p<0.01), BMI (r=0.305; p<0.01), BMR (r=0.158; p<0.01) and weight (r=0.239; p<0.01). Generalized Linear Model (Logit Model) results showed that NP (B=3.497; p<0.01), BMI (B=0.342; p<0.01) and BMR (B=0.004; p<0.01) had significant contribution on weight difference.

Conclusion: BoNT is more effective in normotonic pylorus patients than hypotonic pylorus for weight loss and BMI reduction.